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TB-500 is one of the more interesting peptides on the market due to its potential for directly healing injuries. Some data, although limited, has also shown the peptide may in fact have heart-healing properties, particularly that of ventricle hypertrophy. However, because full data on TB-500 is so limited, it's very hard to give an honest review beyond "he said she said." But it's also difficult to ignore that many users do tend to heal much faster with it than without, and in some cases, faster than would seem possible.
TB-500 was identified as a gene that was up-regulated four-to-six fold during early blood vessel formation and found to promote the growth of new blood cells from the existing vessels. This peptide is present in wound fluid and when administered subcutaneously, it promotes wound healing, muscle building and speeds up recovery time of muscles fibres and their cells. An additional key factor of TB-500 is that it promotes cell migration through a specific interaction with actin in the cell cytoskeleton. It has been demonstrated that a central small amino acid long-actin binding domain has both blood cell reproduction and wound healing characteristics. These characteristics are uncovered by accelerating the migration of endothelial cells and keratinocytes. It also increases the production of extracellular matrix-degrading enzymes.
---Other activities of TB-500
TB-500 has been known to promote at least partial regrowth of hair which has been lost to male-pattern baldness, to darken at least a portion of hair which has grayed, and is reported to enhance muscle mass in horses. The latter effect may be due to promoting differentiation of satellite cells. Bodybuilders who have used TB-500 for healing purposes have however generally not reported such an effect. However, it might be that the effect occurred, but was attributed to other causes, or that effect did not occur because TB-500 is generally used only when injured, which tends not to be a time of training for best gains.
I wouldn't use TB-500 for the purpose of mass gains, but while using it would keep in mind that uninjured body parts might obtain a benefit from its use, and would train uninjured weak body parts especially hard while doing a TB-500 course, on the chance of benefit. In my personal use, it does seem likely there was some such effect, without having had the knowledge beforehand of muscle gain in horses. I had no expectation of muscle size or "quality" benefit at all.
TB-500 is a peptide which can be quite beneficial for healing of injuries, both acute and chronic, and for treatment of tendinitis. It can also improve flexibility where this has been impaired by injury, and in some cases has partially regrown lost hair. The ordinary course of treatment is 2.0 or 2.5 mg taken by injection twice per week for 4-6 weeks, followed by monthly or twice-monthly injection of 2.0 or 2.5 mg as needed.
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